Baseline plasma-informed circulating tumor DNA analyses comparing multiplex digital PCR and NGS for longitudinal monitoring in Hodgkin lymphoma
Year: 2026
Type: article
Abstract: Despite excellent cure rates in Hodgkin lymphoma (HL) [ 1 ], 10–15% of patients experience primary treatment failure or long-term treatment-associated complications due to overtreatment [ 2 , 3 ]. Currently, interim positron emission tomography–computed tomography (PET/CT) with 18 F-fluorodeoxyglucose, after two chemotherapy cycles, guides therapy in advanced stage-disease [ 4 ]. However, PET/CT has limited specificity, resulting in frequent false-positive and occasional false-negative findings [ 5 ]. underscoring the need for sensitive molecular tools for treatment response assessment and detection of measurable residual disease (MRD).
Source: Blood Cancer Journal
Authors: Zahra Haider, Linn Deleskog Spångberg, Karin E. Smedby, Olha Krynina, Cecilia Jylhä, Irina Savitcheva, Emil Lundin, Marzia Palma, Lotta Hansson, Leonie Saft, Blaž Oder, Anna Lyander, Moa Hägglund, Anna Gellerbring, Mathias Johansson, Karl Nyrén, Richard Rosenquist, Tove Wästerlid, Emma Tham
Language: English
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $5,290
OpenAlex ID: W7166330907