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Early dysanapsis in experimental bronchopulmonary dysplasia: implications for lifelong lung disease

Year: 2026

Type: article

Abstract: Disruptions during perinatal lung development can lead to chronic lung diseases such as bronchopulmonary dysplasia (BPD). Rats exposed to a single intraamniotic endotoxin injection were evaluated for BPD-associated parameters of lung structure and function on postnatal days 14 and 28, akin to human infancy and childhood. Endotoxin-exposed rats demonstrated persistent impairments in lung development and function. This is the first preclinical study to suggest that early dysanaptic growth may predispose to lifelong impaired lung function.

Source: American Journal of Physiology-Lung Cellular and Molecular Physiology

DOI: 10.1152/ajplung.00152.2026

Authors: Elizabeth A. McGinn, Alexander Sosa, Mary Corrigan, Gregory Seedorf, Jennifer Mecklenburg, Livia A. Veress, Steven H. Abman, Bradford J. Smith, Erica W. Mandell

Institution: University of Colorado Anschutz

Language: English

Topic: Neonatal Respiratory Health Research

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: National Institutes of Health, National Heart, Lung, and Blood Institute, National Center for Advancing Translational Sciences, Eunice Kennedy Shriver National Institute of Child Health and Human Development

Awards: G1076000741, G131589059, G1544622754, G2335238897, G5527787473, Colorado Clinical and Transational Sciences Institute, Multidisciplinary Research Training in Pediatric Pulmonary Vascular Disease, The Role of Developmental Dysanapsis in Lung Development Throughout the Lifespan in Experimental Bronchopulmonary Dysplasia, G936337638

OpenAlex ID: W7166339567

FWCI:

Cites: 100

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