Work

Characterization of intracranial pressure variations in ventricular and subarachnoid spaces of the rat brain

Year: 2026

Type: article

Abstract: This study demonstrates that intracranial pressure (ICP) in healthy rats contains reproducible slow oscillations resembling human B-waves, with timing differences indicating ventricular origin and outward propagation through CSF spaces. These findings provide direct physiological evidence that B-like waves are intrinsic features of normal CSF dynamics rather than purely pathological signals, supporting a neurogenic contribution to ICP regulation and establishing rats as a tractable model for studying their underlying mechanisms.

Source: Journal of Applied Physiology

DOI: 10.1152/japplphysiol.00196.2026

Authors: Cesar Hernandez-Isidro, Christopher L. Passaglia

Institution: University of South Florida

Language: English

Topic: Cerebrospinal fluid and hydrocephalus

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funder: National Institutes of Health