Year: 2015
Type: article
Abstract: Leucine-rich α 2 -glycoprotein (LRG) is a serum glycoprotein in which leucine-rich repeats were first discovered.Although the function of LRG is unknown, increases in the serum level of LRG have been reported in various diseases.In the present study, we found that LRG was induced by recombinant human IL-6 in human hepatoma HepG2 cells.The induction of LRG by IL-6 was up-regulated synergistically with either IL-1β or TNFα in a pattern similar to those for type I acute-phase proteins.We also found that lipopolysaccharide administered intraperitoneally to mice enhanced dose-dependently the expression of LRG mRNA in the liver as well as that of mouse major acute-phase proteins.These results strongly suggest that LRG is a secretory type I acute-phase protein whose expression is up-regulated by the mediator of acute-phase response.LRG might be useful in qualitative assessments as a biomarker for certain diseases including microbial infections.
Language: Japanese
Subfield: Hepatology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W197446402