Colour Doppler Ultrasonographic Evaluation of Vascular Healing Dynamics After Endodontic Surgery Using Platelet-Rich Fibrin and Chorion Membranes: A Randomized Controlled Trial
Year: 2026
Type: preprint
Study designs: Randomized Controlled Trial, Clinical Trial
Abstract: Objectives This study evaluated periapical healing and vascular response following endodontic surgery with platelet-rich fibrin and chorion membranes in combination with hydroxyapatite graft. Healing was assessed using ultrasonography and colour Doppler imaging. Materials and Methods This randomized controlled trial included 48 patients needing endodontic surgery for single-rooted front teeth with periapical lesions between 8 and 20 mm. Patients were divided into three groups: one received only hydroxyapatite graft, another received platelet-rich fibrin membrane with hydroxyapatite, and the third received chorion membrane with hydroxyapatite. All patients underwent the same surgical steps: cleaning, root-end removal, ultrasonic preparation, and filling with mineral trioxide aggregate. Ultrasonography and colour Doppler imaging were performed at baseline, 1 month, and 6 months. The researchers measured lesion surface area, volume, and peak systolic velocity. Results All groups demonstrated marked decreases in lesion surface area and volume over time. After 6 months, intergroup differences in surface area and volume reduction were not statistically significant. The chorion membrane group exhibited the greatest numerical reduction in lesion size and a substantially higher peak systolic velocity at 6 months. Conclusions Both platelet-rich fibrin and chorion membranes facilitated periapical healing when combined with hydroxyapatite graft. The chorion membrane group demonstrated a stronger vascular response on Doppler imaging; however, superiority for hard-tissue healing was not established. Clinical Relevance Colour Doppler ultrasonography offers a non-ionising modality for evaluating vascular healing following endodontic surgery.
Source: Research Square
Institution: King George's Medical University
Language: English
Subfield: Oral Surgery
Field: Dentistry
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7166504074