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COVID-19 Vaccine-triggered Relapsing Immune Dysregulation: An Observational Study with Four-year Follow-up

Year: 2026

Type: article

Abstract: Background Vaccination against COVID-19 infection became mandatory because of the field situation during the pandemic. Purpose Vaccine efficacy and safety need many field years of study; time constraints due to the pandemic limited the same. A hospital-based study was done in South India among patients who presented with immune-mediated disorders in temporal correlation with COVID-19 vaccination. Methods The study period was 20 months, from March 2020 to November 2021. There were a total of 3,235 patients with neurological issues seen in two tertiary institutions, catering predominantly to patients from lower socio-economic strata in South India. A total of 1,007 (31.12%) patients had received COVID-19 vaccination (single dose in 511 [50.7%] and both doses in 496 [49.3%]). The general prevalence of primary demyelinating disease was compared with the background of vaccine-induced demyelination. Chi-square test was utilised for determining the association between neurological sequelae and the type of vaccine administered. Results Eighteen patients had neurological sequelae, and 16 had a monophasic pattern. Recurrent autoimmunity was seen in two patients who took the Sputnik vaccine. Comparing the prevalence of primary multiple sclerosis (MS) versus vaccine-induced demyelination, there was a statistically significant difference ( χ 2 = 572.38; p < .001), which indicates a definite role of vaccination in these patients. The association between neurological manifestations of Covishield and Covaxin showed no statistically significant difference in neurological sequelae ( χ 2 = 0.0466; p = .8). The Sputnik vaccine was not considered, as the number was less than five. Anti-myelin oligodendrocyte glycoprotein-associated recurrent optic neuritis was seen in one patient, and tongue atrophy, pyramidal signs, ulcerative colitis and arthritis after 3 months, and C-ANCA positivity were seen following the Sputnik vaccine in one patient. Conclusion Vaccination is an effective public health intervention. However, in susceptible individuals, it can probably trigger a recurrent and multisystem event by immune dysregulation. The association is an observation-based postulate that needs a longer, larger follow-up. As per this study, it is non-fatal and remits permanently.

Source: Annals of Neurosciences

DOI: 10.1177/09727531261434290

Authors: C. S. Vidhya Annapoorni, S. R. Chandra, Thomas Gregor Isaac

Institutions: Government of Kerala, Indian Institute of Science Bangalore

Language: English

Topic: SARS-CoV-2 and COVID-19 Research

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $395