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Adrenaline-induced hypokalemia and critical QT prolongation in a patient with refractory anaphylactic shock complicated by myocardial ischemia: a case report

Year: 2026

Type: article

Abstract: Introduction: Adrenaline is the first-line treatment for anaphylactic shock. However, adrenaline administration may exacerbate myocardial ischemia and induce fatal arrhythmias. It can also cause hypokalemia, thereby increasing the risk of life-threatening cardiac events. Case presentation: A 58-year-old man developed refractory anaphylactic shock accompanied by electrocardiographic evidence of myocardial ischemia during spinal fusion surgery. A total of 3.6 mg of intravenous adrenaline was required. At 135 minutes after onset, the serum potassium level decreased to a nadir of 2.1 mmol/L, resulting in critical QT prolongation. Timely adrenaline discontinuation and potassium supplementation resolved the hypokalemia, resulting in a favorable outcome. Discussion: Adrenaline is known to induce hypokalemia through a rapid and severe intracellular potassium shift via β2-adrenergic stimulation; however, this effect may be underestimated. The synergistic interaction of myocardial ischemia during anaphylactic shock, the direct adverse effects of adrenaline on the myocardium, and adrenaline-induced hypokalemia significantly increases the risk of fatal arrhythmias. Conclusion: When using multiple and/or continuous doses of adrenaline, clinicians should consider proactive monitoring of potassium levels and potassium supplementation, thereby preventing life-threatening arrhythmias.

Source: Annals of Medicine and Surgery

DOI: 10.1097/ms9.0000000000005294