Work

Nuclear adaptation in cell migration

Year: 2026

Type: review

Abstract: Cells in tissues often navigate complex environments, encountering physical obstacles which impose mechanical confinement. The nucleus -the largest organelle of the eukaryotic cell-is emerging as a key platform for integrating mechanical signals from the extracellular environment. A mechanically stiff nucleus often limits migration through confinement. It is becoming increasingly clear that the nucleus does not passively resist forces. Subnuclear organisation can change upon mechanical stress, revealing an impressive capability for adaptation to environmental challenges that underpins cell function, developmental potential and can support invasion and migration both in physiology and disease.

Source: Current Opinion in Cell Biology

DOI: 10.1016/j.ceb.2026.102668

Authors: You-Hsuan Liu, Elena Scarpa

Institution: University of Cambridge

Language: English

Topic: Nuclear Structure and Function

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $4,390

Funders: Royal Society, Cambridge Trust, Medical Research Council