Work

Nanocarrier‐Based Gene Delivery Systems: Mechanisms, Clinical Translation, and Future Perspectives

Year: 2026

Type: article

Abstract: Gene therapy holds revolutionary potential for managing genetic disorders, cancers and infectious illnesses. However, one of the biggest challenges is delivering DNA or RNA into targeted cells and in the safe and effective way. In this review, nano carrier-based approaches for gene delivery are critically examined, focusing on both viral and non-viral systems. The advancement of CRISPR-Cas genome editing, machine learning-assisted nanocarrier optimization, and biologically inspired delivery systems is being quickly pushed forward in this area. In this review, a comparative analysis of gene delivery systems is being provided, and the key challenges to clinical translation are being pointed out. In addition, expert opinions on future research directions are being offered, with a heavy focus on the development of multifunctional, precisely targeted, and easily scalable delivery systems that can be integrated with next-generation therapeutic technologies.

Source: Biotechnology and Bioengineering

DOI: 10.1002/bit.70289

Authors: Rahat Fatima Naqvi, Muhammad Ali, Sadia Ahmed Zuberi, Nimra Aamir, Samra Rafique

Institutions: Salim Habib University, University of Lahore

Language: English

Topic: RNA Interference and Gene Delivery

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W7166529934