Work

The Exploration of TPhos as a Monodentate P-Ligand for Palladium-Catalyzed Regioselective Hydrothiocarbonylation of Styrenes under Neutral Conditions

Year: 2026

Type: article

Abstract: A palladium-catalyzed nonacidic hydrothiocarbonylation of styrenes with CO and thiols has been developed. Utilizing a cyclopropane-based monophosphine ligand (TPhos), this protocol enables the efficient and branched-selective synthesis of alkyl thioesters under mild and neutral conditions with broad substrate scope and excellent functional group tolerance.

Source: Organic Letters

DOI: 10.1021/acs.orglett.6c02424

Authors: Chang-Sheng Kuai, Wen Che, Shou-Fei Zhu, Xiao-Feng Wu