Year: 2026
Type: preprint
Abstract: Capturing infrequent or context-dependent brain events, such as epileptic seizures and sleep abnormalities, often requires continuous monitoring over several days. It is most practical and scalable when achieved with unobtrusive, high-fidelity wireless systems that patients can use at home. Current electroencephalography systems restrict patient mobility and require continuous electrode maintenance and sub-scalp solutions require surgical implantation that offer limited spatial coverage. We developed NeuroWeaves, gold-polyimide microthreads thinner than a human hair that can be stitched through the epidermis using standard suture tools and connected to a lightweight wireless recorder. In preclinical models, NeuroWeaves captured whisker-evoked potentials with accuracy comparable to skull screws and matched the performance of a commercial acquisition benchmark. Semi-chronic recordings in freely moving animals remained stable for several weeks, and 30-day histology showed minimal inflammation comparable to surgical sutures. Pilot human studies reproduced posterior-dominant rhythms, photic responses, chewing artifacts, and sleep oscillations comparable to clinical electrodes. These results establish a minimally invasive, biocompatible neural interface that represents a new modality for high-fidelity brain monitoring beyond conventional laboratory and clinical constraints.
Source: medRxiv
Authors: Abdulhameed Abdal, Hyeonseok Kim, Fadi Khoury, Peter Hadar, Brian F. Coughlin, Paige Schumsky, Gillian Celis, Jason Chin, Anthony Navarro, Sarine Krikorian, Samuel J. Edmunds, Ritwik Vatsyayan, Moumita Halder, Tarek Rafeedi, Jiahao Wan, Rachel Blau, Kaushik Shukla, Tianhai Wu, Jesse Jokerst, Darren J. Lipomi, Sydney S. Cash, Shadi A. Dayeh
Language: English
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
Funders: National Science Foundation, Weizmann Institute of Science, Kuwait Foundation for the Advancement of Sciences, National Institutes of Health, University of California, San Diego, National Cancer Institute, National Institute of Neurological Disorders and Stroke, Air Force Office of Scientific Research
OpenAlex ID: W7166531371