Year: 2026
Type: article
Abstract: Lipid droplets (LDs) are dynamic organelles that support homeostasis and shield cancer cells from stress to promote cancer cell survival, progression, and therapy escape. Here, we summarize recent findings demonstrating LD crosstalk with other organelles and the immune/stromal compartments aimed at buffering metabolic, oxidative, proteotoxic, and lipotoxic stress and stress from cancer treatment and the anti-tumor immune response. We briefly summarize current experimental approaches, including imaging, biochemical, and functional approaches, used to study LD biology. Together, these findings place LDs at the center of cancer cell homeostasis and highlight their emerging potential as translational targets in cancer therapy.
Source: Communications Biology
Authors: Ruolun Wei, Claudia K. Petritsch
Institutions: Stanford Medicine, Stanford University, Stanford Cancer Institute
Language: English
Subfield: Biochemistry
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $4,190
Awards: Investigating ASPM regulation of asymmetric division for therapeutic opportunities, A causal role for asymmetric cell division defects in glioma initiation, BRAF Mutation in Malignant Astrocytoma Origin, Evolution, and Response to Therapy, Deconvolution and interruption of the cancer-neuro-immune axis facilitating brain metastases
OpenAlex ID: W7166552132