Work

Sensitive and Selective Detection of Purine Drugs on Au/MIL-101(Cr) by SERS

Year: 2026

Type: article

Abstract: The detection of purine drugs has been a persistent concern among scientists in the biology and medicine fields over the past few decades. However, achieving both high sensitivity and selectivity in the detection of purine drugs sharing similar molecular structures remains a significant challenge. Herein, we achieve both high detection sensitivity and selectivity for purine drugs with similar structure on the Au/MIL-101 composite by surface-enhanced Raman scattering (SERS). In the water solution, the detection sensitivity for adenine (Ade) is as low as 1 ng·mL-1. Importantly, in serum containing Ade, 6-MP and ALP, Ade can be selectively detected with detection limit of 3 ng·mL-1, indicating excellent anti-interference capability and practical application potential. Such high detection sensitivity is attributed to the specific adsorption between the amino group of the adenine and the carboxyl groups of the MIL-101(Cr). This work provides a strategy for detecting structurally similar drugs and illustrates the potential use of functionalized SERS substrates in pharmaceutical analysis and therapeutic drug monitoring.

Source: The Journal of Physical Chemistry C

DOI: 10.1021/acs.jpcc.6c03094

Authors: Jing-Jing Li, Can-Jun Zou, Wei Tang, Cheng-Yu Zhang, Jian-Hua Jia, Ping-Ping Fang

Institution: Sun Yat-sen University

Language: English

Topic: Gold and Silver Nanoparticles Synthesis and Applications

Subfield: Electronic, Optical and Magnetic Materials

Field: Materials Science

Domain: Physical Sciences

Open Access status: green

Funder: National Natural Science Foundation of China

Award: G7319229425