Work

The WISDOM Trial and the Evidence Base for Risk-based Breast Cancer Screening

Year: 2026

Type: article

Abstract: Breast cancer screening recommendations continue to rely largely on age, despite substantial variation in individual risk.Advances in risk prediction, including the incorporation of breast density, polygenic risk scores (PRS), and germline susceptibility variants, have renewed interest in screening strategies that adapt screening intensity according to individual risk rather than age alone.However, evidence supporting risk-based screening has largely been derived from observational studies and simulation models.In this issue, Esserman and colleagues report the results of the Women Informed to Screen Depending on Measures of Risk (WISDOM) randomized clinical trial, providing the first large-scale randomized evaluation of a comprehensive risk-based screening strategy.

Source: Cancer Screening and Prevention

DOI: 10.14218/csp.2026.00008

Authors: Marc Poirot, Philippe de Médina, Sandrine Silvente-Poirot

Institutions: Centre National de la Recherche Scientifique, Inserm, Centre de Recherches en Cancérologie de Toulouse, Université de Toulouse

Language: English

Topic: Digital Radiography and Breast Imaging

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W7166560373