Work

Small Molecule Stabilization of Diverse Amyloidogenic Immunoglobulin Light Chains Revealed by Hydrogen–Deuterium Exchange Mass Spectrometry

Year: 2026

Type: article

Source: Journal of Molecular Biology

DOI: 10.1016/j.jmb.2026.169917

Authors: Daniele Peterle, Nicholas L. Yan, Elena S. Klimtchuk, Bindu Y. Srinivasu, Vesna Brusic, Derek Rhoades, Thomas E. Wales, Olga Gursky, Jeffery W. Kelly, John R. Engen, Gareth J. Morgan

Institutions: Northeastern University, Scripps Research Institute, Boston University

Language: English

Topic: Amyloidosis: Diagnosis, Treatment, Outcomes

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Boston University, National Institutes of Health, National Heart, Lung, and Blood Institute, National Institute of General Medical Sciences

Awards: Apolipoprotein conformation in amyloid and cardiovascular diseases, Structure and Function of Serum Amyloid A in Health and Disease, Probing the Proteinopathy Component of Light Chain Amyloidosis Pharmacologically

OpenAlex ID: W7166566043

FWCI: 4.104

Cites: 70

Cited by: 2

Related to: 10