Work

The vitamin rheostat: A unified model of epigenetic feedback in vitamin homeostasis

Year: 2026

Type: article

Abstract: Recent evidence implicates epigenetic mechanisms in vitamin metabolism, yet most studies remain focused on individual vitamins. In this mini-review, we extend beyond single-vitamin paradigms to propose the Vitamin Rheostat: a unifying model in which vitamins influence regulatory signaling networks that shape their own uptake, utilization, and degradation. By integrating fat-soluble vitamins (nuclear receptor-mediated signaling) and water-soluble vitamins (methyl-donor and enzymatic cofactor systems), this model provides a predictive and experimentally testable framework that may help explain inter-individual variability in response to vitamin intake. It repositions epigenetics as an active mediator in vitamin homeostasis and supports the development of chromatin-informed approaches to precision nutrition.

Source: Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms

DOI: 10.1016/j.bbagrm.2026.195164

Authors: Ruslan Kubant, G. Harvey Anderson, Mykhailo Korda

Institutions: University of Toronto, I.Horbachevsky Ternopil National Medical University

Language: English

Topic: Epigenetics and DNA Methylation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,840