Work

N-linked glycosylation regulates SNAT2 trafficking and stability in pancreatic ductal adenocarcinoma cells

Year: 2026

Type: article

Abstract: This study provides evidence that the localization of human SNAT2 to the plasma membrane requires N-linked glycosylation in PDAC cell lines. To our knowledge, our report is the first to show that localization of SNAT2 to the cell surface is important for supporting PDAC cell proliferation. This work establishes tools to investigate the significance of lysosomal SNAT2 and supports the concept that targeting nutrient transporter glycosylation may represent a viable strategy to limit PDAC growth.

Source: American Journal of Physiology-Cell Physiology

DOI: 10.1152/ajpcell.00060.2026

Authors: Jessica C. Koe, Kiana Pashaoskooie, Danisha Johal, Yuxi C. Zhong, Caiyun Wu, Seth J. Parker

Institutions: University of British Columbia, BC Children's Hospital Research Institute

Language: English

Topic: Glycosylation and Glycoproteins Research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid