Work

Painful gastric glitch: an acute epigastric pain triggered by specific food as a new phenotype of postprandial epigastric pain syndrome

Year: 2026

Type: article

Abstract: BACKGROUND AND AIM: Postprandial epigastric pain syndrome was recently suggested as a disorder of gut-brain interaction. We assessed gastroduodenal motility and histology in patients with acute epigastric pain triggered by specific foods. METHODS: In this case-control, exploratory study, patients with epigastric pain and matched controls underwent upper endoscopy to exclude organic disease and gastroduodenal biopsies for histology. All participants underwent a dynamic gastroduodenal MRI, with a baseline acquisition followed by a food-trigger intake and three MRI acquisitions at 15-minute intervals. RESULTS: We studied seven pairs of participants (57% women, 33.3 ± 10.7 years old), all with unrevealing endoscopy. During the MRI, epigastric pain patients had pain crises that scored 6.6 ± 2.4 of a maximum of 10 points, triggered by caipirinha, red wine, banana, and coffee. No control subject had a pain crisis. Epigastric pain patients and controls did not differ in gastric motor parameters (P > 0.05), including accommodation, wall motion, and gastric emptying. Epigastric pain patients showed a negative correlation between pain score and wall motion time to peak (r = -0.81, P = 0.027). The duodenal mast cell count was higher in epigastric pain patients than in controls [median 140 (interquartile 25-75%: 117-153) vs. 86 (76-117); P = 0.020]. CONCLUSIONS: In patients presenting with acute epigastric pain following specific food intake, pain intensity might correlate with gastric wall motion parameters and duodenal mast cell infiltration. After confirmatory studies, such a postprandial epigastric pain syndrome might be recognized as a painful gastric glitch.

Source: BMC Gastroenterology

DOI: 10.1186/s12876-026-05060-5