Work

ALOX15 links lipid metabolism to receptor trafficking in platelet activation

Year: 2026

Type: article

Abstract: Platelet activation is traditionally viewed as a signaling process initiated by receptor engagement. In this issue of The FEBS Journal, Govatati et al. identify an additional regulatory layer linking lipid metabolism to receptor trafficking. The authors show that ALOX15-derived lipid mediators promote PKCθ-NMT1-dependent myristoylation of PAR4, thereby facilitating its membrane localization and platelet activation. These findings position receptor lipidation and trafficking as active regulatory mechanisms in platelet activation and suggest new opportunities for therapeutic modulation of hemostasis.

Source: FEBS Journal

DOI: 10.1111/febs.70637

Authors: Yosef Eshetie Amare, Sharad Saxena, Serena Zacchigna

Institutions: University of Nova Gorica, International Centre for Genetic Engineering and Biotechnology, University of Trieste

Language: English

Topic: Platelet Disorders and Treatments

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $5,000