Work

In Vitro Phantom Solution for $^{129}$Xe HyperCEST: Preclinical Sequence Optimization Under Enhanced Relaxation

Year: 2024

Type: conference-paper

Abstract: Xenon-129 HyperCEST measurements improve the sensitivity and specificity of molecular diagnostics with NMR/MRI. However, the translation from in vitro to in vivo applications requires further research. Challenges include reduced relaxation times and lower concentrations of hyperpolarized gas (hp) in the target tissue, leading to reduced signal intensity. To address this, an in vitro phantom solution that mimics the relaxation times of blood was developed to pre-evaluate the acquisition parameters and saturation optimization.

Source: Zenodo (CERN European Organization for Nuclear Research)

DOI: 10.5281/zenodo.20812806

Authors: Gerbeth, Hannah Louise, Schröder, Leif

Institutions: German Cancer Research Center, Heidelberg University, Deutsches Konsortium für Translationale Krebsforschung

Language: English

Topic: Atomic and Subatomic Physics Research

Subfield: Atomic and Molecular Physics, and Optics

Field: Physics and Astronomy

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W7166584753

FWCI:

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