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The ER‐Resident Protein PDZD8 Inhibits Virus Production of West Nile Virus

Year: 2026
Type: article
Abstract: West Nile virus (WNV) remodels the endoplasmic reticulum (ER) membrane in cells to aid virus production. However, the molecular mechanisms underlying this process remain unclear. PDZD8 is an ER-resident protein that mediates ER-mitochondria contact and lipid transfer, both of which are associated with membrane remodeling. In this study, we found that WNV infection suppressed the expression of PDZD8, leading to a reduction in ER-mitochondria contact sites. By contrast, PDZD8 suppressed WNV production by inhibiting the processes of viral particle assembly and release. These findings suggest that WNV suppresses PDZD8 expression to partially counteract its inhibitory effect on WNV production.
DOI: 10.1111/1348-0421.70072
Authors: Shiori Abe, Akari Sato, Haruto Eguchi, Keisuke Maezono, Passawat Thammahakin, Duong Thi Ngoc Thuy, Hiroaki Kariwa, Shintaro Kobayashi
Institution: Hokkaido University
Language: English
Field: Medicine
Open Access status: green
Funders: Japan Agency for Medical Research and Development, Research Promotion Foundation, Astellas Pharma, Shionogi, Astellas Foundation for Research on Metabolic Disorders, Japan Society for the Promotion of Science
Awards: G3453774835, G4732634665, Interorganelle communication between nucleus and endoplasmic reticulum in Flavivirus infection, G7313320092, Examination of effects of neural conversion of microglia on neurological sequelae of viral encephalitis, G8157188522
OpenAlex ID: W7166595809
FWCI:
Cites: 33
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