Rapid Elimination of Culturable SARS-CoV-2 With Intramuscular or Intravenous Administration of Antiviral Monoclonal Antibody Therapy
Year: 2026
Type: article
Abstract: We evaluated intramuscular (IM) versus intravenous (IV) administration of tixagevimab/cilgavimab in early COVID-19. Both routes achieved rapid elimination of culturable virus and minimal emergence of resistance. These results support IM delivery as a viable alternative to IV, with important implications for scalable deployment in future viral pandemics.
Source: UNC Libraries
DOI: 10.17615/jsrq-sr92
Authors: Li, Jonathan Z, Fischer, William, Hughes, Michael D, Javan, Arzhang Cyrus, Giganti, Mark J, Fletcher, Courtney V, Soboleva, Karina, Glover, Owen T, Chew, Kara W, Boucau, Julie, Cohen, Taylor, Coombs, Robert W, Smith, Davey, Eron, Joseph J, Streicher, Katie, Choudhary, Manish C, Daar, Eric S, Greninger, Alexander L, Ignacio, Rachel Bender, Gibbs, Michael, Barczak, Amy K, Currier, Judith S, Wohl, David Alain, Aga, Evgenia, Deo, Rinki, Moser, Carlee
Institution: University of North Carolina at Chapel Hill
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funders: Edwards Lifesciences, Univerzita Karlova v Praze, University of Calgary, Health Research Board, ViiV Healthcare, Public Health Agency of Canada, National Energy Research Scientific Computing Center, ResMed, National Institute for Health and Care Research, British Ecological Society, Rhodes Scholarships, Grains Research and Development Corporation, University College Dublin, Deutsche Forschungsgemeinschaft, Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung, Danmarks Grundforskningsfond, Hong Kong Baptist University, University of Sydney, Griffith University, National Natural Science Foundation of China, Ministerstvo Školství, Mládeže a Tělovýchovy, Bundesministerium für Bildung und Forschung, Cancerfonden, Generalitat de Catalunya, China Postdoctoral Science Foundation, Ministerstvo školstva, vedy, výskumu a športu Slovenskej republiky, Ministerstvo Zdravotnictví Ceské Republiky, Nederlandse Organisatie voor Wetenschappelijk Onderzoek, University of Toronto, Korea Research Institute of Chemical Technology, National Research Foundation of Korea, Karolinska Institutet, Vetenskapsrådet, Natural Science Foundation of Shanxi Province, Lietuvos Mokslo Taryba, Ministry of Education, India, KWF Kankerbestrijding, Agentúra na Podporu Výskumu a Vývoja, Latvijas Zinātnes Padome, Barncancerfonden, Natural Science Foundation of Henan Province, Forskningsrådet om Hälsa, Arbetsliv och Välfärd, Universidade de Vigo, Department of Finance of Jilin Province, Servier, Ministère de l’Europe et des Affaires étrangères, King Salman Center for Disability Research, Skaraborg Institute, William Demant Fonden, National Institutes of Health, Substance Abuse and Mental Health Services Administration, School of Medicine, Stanford University, Sichuan Province Science and Technology Support Program, Institute for Physical Activity and Nutrition, Canadian Institutes of Health Research, Natural Sciences and Engineering Research Council of Canada, Engineering and Physical Sciences Research Council, Biotechnology and Biological Sciences Research Council, Japan Society for the Promotion of Science, Natural Science Foundation of Anhui Province, European Regional Development Fund, South China Sea Institute of Oceanology, Chinese Academy of Sciences, National Key Research and Development Program of China, Medical and Health Research Project of Zhejiang Province, Science and Technology Program of Guizhou Province, National Institute on Alcohol Abuse and Alcoholism, National Heart, Lung, and Blood Institute, National Institute of Mental Health, National Institute on Drug Abuse, National Institute of Allergy and Infectious Diseases, Fogarty International Center, National Institute of Diabetes and Digestive and Kidney Diseases, Division of Civil, Mechanical and Manufacturing Innovation, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Daiichi Sankyo Europe, HORIZON EUROPE Health, HORIZON EUROPE European Research Council, Center for Lignocellulose Structure and Formation, Oregon Health Authority
OpenAlex ID: W7166638626