Work

Development of a Second-Generation Stereoselective Manufacturing Process for a Key N -Hydroxyamidine Intermediate of GDC-6599 Enabled by Data Science and Mechanistic Understanding

Year: 2026

Type: article

Source: Organic Process Research & Development

DOI: 10.1021/acs.oprd.6c00017

Authors: Jacob C. Timmerman, Allen Y. Hong, Kurt Püntener, Anna-Lena Glass, Sandro Tonazzi, Katarzyna A. Piechowicz, Maud Guillemot-Plass, José G. Napolitano, Breanna Conklin, Haiming Zhang, Francis Gosselin

Institutions: Genentech, Roche (Switzerland)

Language: English

Topic: Asymmetric Synthesis and Catalysis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: closed

OpenAlex ID: W7166644786

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Cites: 24

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