Work

SGLT2 inhibitors enhance ketogenesis by acting as allosteric activators of the mitochondrial enzyme HMGCS2

Year: 2026

Type: article

Abstract: SGLT2 inhibitors boost ketone production by directly activating a liver enzyme, revealing a new mechanism that may contribute to their heart and kidney benefits.

Source: Journal of Clinical Investigation

DOI: 10.1172/jci192333

Authors: Abdualrahman Mohammed Abdualkader, Xiaobei Li, Yiming Yin, Chenhao Bai, Parisa Pourfarziani, Jiaheng Guan, Sora Kwon, Kyoung-Han Kim, Rami Al Batran

Institutions: Université de Montréal, University of Ottawa, Ottawa Heart Institute

Language: English

Topic: Diabetes Treatment and Management

Subfield: Endocrinology, Diabetes and Metabolism

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $5,200

Funder: Canadian Institutes of Health Research

Award: Exploring the Hepatoprotective Actions of Sodium-glucose Cotransporter 2 (SGLT2) Inhibitors

OpenAlex ID: W7166647676

FWCI: 22.45

Cites: 4

Cited by: 5

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