Work

Transcriptional readthrough progresses from incidental byproduct to therapeutic opportunity

Year: 2026

Type: article

Abstract: Several anti-cancer drugs delay transcription termination, triggering transcriptional readthrough. Readthrough has long been considered an incidental transcriptional byproduct, however a recent study reveals that it can be functional and might even offer a therapeutic opportunity.

Source: Nature Structural & Molecular Biology

DOI: 10.1038/s41594-026-01833-4

Authors: Agata Stępień, Martyna Plens-Gałąska, Kinga Kamieniarz-Gdula

Institution: Adam Mickiewicz University in Poznań

Language: English

Topic: Genomics and Chromatin Dynamics

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $12,690