Study of the Effect of Local Methylprednisolone in Patients of Mastectomy on Seroma Formation
Year: 2026
Type: article
Abstract: have also been used to reduce seroma formation; however, a study shows that drains did not prevent seroma formation and were associated with a longer postoperative stay and higher pain scores after surgery for breast cancer.In patients who had a mastectomy, the use of fibrin sealant reduced the rate of seroma formation.10 A recent study showed that injection of methylprednisolone acetate into the mastectomy cavity as a single dose on the first day after mastectomy with sentinel lymph node biopsy surgery has a significant effect on the prevention of seroma formation.11 The primary objective of this randomized single blind intervention study is to analyze the effect of a single dose of 80 mg local methylprednisolone applied intraoperatively just before flap closure in mastectomy on seroma formation, assessed by measuring total seroma volume, duration of seroma, and surgical complications.Secondary objectives were the correlation IntroductIonSeroma formation is the most prevalent complication after mastectomy and axillary lymph node dissection, and is often considered to be an unavoidable nuisance rather than a serious complication.1 It is an accumulation of serous fluid that develops following the formation of skin flaps during mastectomy or in the axillary dead space in the immediate or acute postoperative period. 2 Ideal wound closure should minimize lymph spillage and serous oozing, provide a means of holding skin flaps securely to the chest wall structures, obliterate dead space, and allow rapid removal of fluid as it forms.For this purpose, several techniques of flap fixation or wound drainage, as well as limitation of postoperative shoulder movement and the use of adhesive glue, have been investigated to improve primary healing and minimize seroma formation.2 However, seromas predispose patients to wound infection, prolonged wound healing, delayed initiation of adjuvant therapy, increased treatment costs, and increased distress.The main pathophysiology of seroma is still poorly understood and remains controversial.The optimal ways to reduce the incidence of seroma formation are unknown.Seromas were traditionally considered to be an accumulation of lymphatic fluid 3 ; however, it has been demonstrated that a seroma is an exudate in response to the surgical trauma 3,4 via the activities of proteinases, proteinase inhibitors, cytokines, and growth factors.5,6 Suppressing this inflammatory response by means of steroid administration has been performed for different operations.Methylprednisolone pretreatment represents a potentially important biological modifier of perioperative inflammatory responses.7 Administration of triamcinolone into the wound cavity after autologous latissimus dorsi breast reconstruction reduced seroma formation, 8 whereas a single bolus intravenous dose of methylprednisolone before mastectomy exerted no effect.9 Drains and fibrin sealants
Source: Journal of Medical Academics
Institutions: SMS Medical College, Government Medical College
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W7166697165