Pd/C‐Catalyzed Hydrogenation of CF 3 ‐, CF 2 H‐, and CF 2 CO 2 Et‐containing Pyridines: A Robust Method for Highly Functionalized containing Piperidines
Year: 2026
Type: article
Abstract: Et groups has been developed. Using an inexpensive heterogeneous Pd/C catalyst, diversely functionalized fluorinated piperidines were synthesized under air- and moisture-tolerant reaction conditions (37 examples, up to 98% yield) with good to high diastereoselectivity. Comprehensive NMR studies enabled full structural characterization of the synthesized fluorinated compounds. The synthetic utility of the methods was further highlighted by the gram-scale preparation of the fluorinated scaffolds and the synthesis of a trifluoromethylated analog of the antipsychotic drug melperone.
DOI: 10.1002/anie.4352204
Language: English
Subfield: Pharmaceutical Science
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $5,510
Funders: Sanofi, Agence Nationale de la Recherche
OpenAlex ID: W7166717396