Olanzapine Use and Vomiting Incidence in Chemotherapy-receiving Patients With Cervical Cancer: Multicenter Post Hoc Analysis
Year: 2026
Type: article
Abstract: BACKGROUND/AIM: in concurrent chemoradiotherapy (CCRT) for cervical cancer is classified as highly emetogenic chemotherapy (HEC), in which the concomitant use of olanzapine is recommended. However, in Japan, the clinical use of olanzapine remains limited owing to pharmacokinetic concerns and contraindications. We aimed to clarify the real-world patterns of olanzapine use and its association with vomiting incidence in patients with cervical cancer undergoing CCRT. PATIENTS AND METHODS: This post hoc analysis used data from a multicenter collaborative study of 961 patients with cervical cancer who received CCRT between January 2016 and March 2024. Patient characteristics and antiemetic use, including olanzapine and its dosage, were recorded. Vomiting within six days after the first cisplatin administration was evaluated. Time to vomiting onset was analyzed using Kaplan-Meier methods and multivariate Cox proportional hazards models. RESULTS: 7.6% in users and non-users, with no significant difference, and time to vomiting onset did not differ. Multivariate analysis adjusted for age, neurokinin 1 receptor antagonist use, type of 5-hydroxytryptamine type 3 receptor antagonist, smoking history, and alcohol consumption history showed no significant difference. Among stage IV patients, olanzapine <5 mg/day was more common. CONCLUSION: Olanzapine use in patients with cervical cancer undergoing CCRT remained limited and was selectively prescribed to younger high-risk patients. No significant difference in vomiting control was observed, suggesting patient selection bias may have influenced characteristics.
Source: In Vivo
Authors: YUSUKE KAWAMURA, KENSUKE YOSHIDA, HAJIME MORITA, MASAKI NAKAI, TAKUMA MATSUMOTO, YOSHINOBU GOHARA, NAOTO HOSHINO, NAOYA TONOMURA, MANAMI BANBA, AYAKO YAMAGUCHI, MASAKI TACHIBANA, TOMOKI FUKUSHIMA, HIROKI HOSOKAWA, TAKUYA MURA, TSUYOSHI YABUKI, SHINICHI WATANABE, ATSUSHI WATANABE, MUNETOSHI SUGIURA
Institutions: Hiroshima City Hiroshima Citizens Hospital, Tokyo University of Pharmacy and Life Sciences, St. Marianna University Hospital, Ehime University Hospital, Shikoku Cancer Center, Saga University, Niigata University Medical and Dental Hospital, Tokyo Metropolitan Tama Medical Center, Aomori Prefectural Central Hospital, Yamagata University, Yamagata University Hospital, Nagaoka Red Cross Hospital, University of Yamanashi Hospital, Nagaoka Chuo General hospital, Iwakuni Medical Center, Uonuma kikan Hospital, Matsuyama University
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W7166744470