Quantitative Assessment of Polydioxanone Microsphere Fillers for Nasolabial Fold Correction: A Comparative Study
Year: 2026
Type: article
Study design: Clinical Trial
Abstract: BACKGROUND/AIM: Dermal fillers are essential tools for facial rejuvenation. This study evaluated the clinical efficacy and safety of a polydioxanone (PDO)-based filler from UltraV, compared with established commercial alternatives for improving nasolabial fold wrinkles. MATERIALS AND METHODS: Thirty-one participants (aged 20-59 years) were enrolled in this prospective, split-face comparative study. Each participant received 1 ml of the test product on one side of the face and an equivalent volume of a control filler on the contralateral side. Skin texture and sunken volume were quantified using ANTERA 3D CS imaging technology (Miravex, Dublin, Ireland) at three time points: baseline, four weeks after the first injection, and four weeks after the second injection. The imaging system's internal software was used to perform topographical analysis of skin surface changes. RESULTS: 9.50% for polynucleotide (PN)]. Skin texture improvement in the PDO group reached 12.07%, a 2.22 fold increase compared to the PDLLA group. CONCLUSION: PDO filler demonstrated favorable clinical efficacy in enhancing skin texture and volume, achieving improvements that were comparable to those of established fillers. These objective findings support PDO fillers as a viable nonsurgical option for facial rejuvenation.
Source: In Vivo
Authors: NGUYEN NGAN GIANG, LINH THI THUY LE, CAIJUN JIN, SHUYI ZHOU, HAN JIN KWON, JUNG RYUL HAM, WON KU LEE, PARK YOUNG MIN, YONG HYUN LEE, PHAM NGOC CHIEN, CHAN YEONG HEO
Language: English
Subfield: Dermatology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W7166770740
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