Retrospective Observational Study of Microbiological Profile and Antibiotic Susceptibility Patterns of Urine Samples Received in a Regional Cancer Hospital
Year: 2026
Type: article
Study design: Observational Study
Abstract: Urinary tract infections are usually treated with antibiotics; however, the widespread empirical use of these drugs without appropriate susceptibility testing has significantly contributed to the rise of antimicrobial resistance among UTI isolates.As a result, antibiotic choice for empirical and rational treatment has become very difficult.3 The prevalence of antibiotic-resistant uropathogens is likely to limit the effectiveness of our current antibiotic arsenal. IntroductIonCancer remains a major cause of mortality worldwide, with over half of all cases occurring in developing countries.Urinary tract infections (UTIs) are among the most common infectious diseases in humans and represent a public health concern due to their significant financial burden. 1 While UTIs are most commonly caused by bacteria, fungal and viral pathogens can also be involved.In immunocompromised patients, UTIs are a leading cause of fever and morbidity (Fig. 1).The primary causative agents are gram-negative bacilli (GNB), though gram-positive organisms may also contribute.Escherichia coli is the most prevalent pathogen, accounting for 75-95% of cases, followed by Klebsiella pneumoniae, other members of the Enterobacteriaceae family, and gram-positive species such as Enterococcus, Staphylococcus, and group B Streptococci (Fig. 2).Although coagulase-negative staphylococci (CoNS) rarely cause symptomatic infections, they are frequently isolated from urine samples.Candida species are commonly isolated from patients who have undergone prolonged or repeated courses of antimicrobial therapy or who have indwelling urinary catheters.
Authors: Vipul Parmar, Tanvi Gohel, Purav Patel
Institution: Gujarat Cancer & Research Institute
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W7166840080