Supplementary Figures S1-S9 from Rapid Transcription Dynamics Confers Cytarabine Resistance in Acute Myeloid Leukemia
Year: 2026
Type: supplementary-materials
Abstract: Figure S1. The effects of short-term AraC treatment on RNA transcription dynamics and AraC resistance acquisition. Figure S2.Absence of genetic clonal selection in rapid AraC resistance development. Figure S3. Suppression of RNA induction interferes with the acquisition of AraC resistance in NB4 and MOLM14. Figure S4. Transcriptomic profiling identifies key role of AraC-rapid response TFs (ARRTFs) in acquisition of drug resistance. Figure S5. Not all hematopoiesis-related TFs are transcriptionally activated following AraC treatment. Figure S6. Transcription dynamics after AraC treatment inNB4. Figure S7. Modest changes in chromatin accessibility (detected by ATACseq) during the development of rapidAraC drug resistance. Figure S8. Flow cytometry gating strategy for analyzing RNA dynamics in hematopoietic stem and progenitor cells (HSPCs) of AMLpatient samples. Figure S9. Evaluation of cell proliferation of control and TF-KO subclones in steady state.
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W7166865102