Work

The metabolic-immune axis in MASH: is the macrophage signature the key to liver disease staging?

Year: 2026

Type: article

Abstract: The clinical management of metabolic dysfunction-associated steatohepatitis (MASH) hinges on accurate staging, yet liver biopsy remains the invasive gold standard (1). Non-invasive biomarkers that capture the dynamic interplay between metabolic stress and immune remodeling are urgently needed. The advent of high-throughput omics techniques, even at the single-cell or nuclear level, has shed light on the role of immune cells in metabolic dysfunction-associated steatotic liver disease (MASLD) and its progression to MASH (2).

Source: Journal of Lipid Research

DOI: 10.1016/j.jlr.2026.101096

Author: Carlos Jose Pirola

Institutions: Consejo Nacional de Investigaciones Científicas y Técnicas, Universidad Maimónides

Language: English

Topic: Liver Disease Diagnosis and Treatment

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,430