Work

Rapid screening platform for peptide prenyltransferases to diversify pseudo-natural prenylated peptides

Year: 2026

Type: article

Source: Nature Catalysis

DOI: 10.1038/s41929-026-01560-5

Authors: Sumika Inoue, Shunya Matsushita, Sayaka Ito, Marin Yokomine, Masayuki Satake, Chikako Okada, Keisuke Hamada, Yuchen Zhang, Risa Ohta, Taro Shiraishi, Hiroaki Suga, Masahiro Okada, Toru Sengoku, Yuki Goto

Institutions: Kanagawa University, The University of Tokyo, Kyoto University, Yokohama City University, RIKEN, Toyota Physical and Chemical Research Institute

Language: English

Topic: Microbial Natural Products and Biosynthesis

Subfield: Pharmacology (medical)

Field: Medicine

Domain: Health Sciences

Open Access status: green

Funders: Japan Agency for Medical Research and Development, Japan Society for the Promotion of Science, Japan Science and Technology Agency

Awards: G124242002, 天然物生合成酵素の流用によるタンパク質の脂質ラベル法の開発, Challenges to the remaining issues of therapeutically valuable pseudo-natural peptides and products, G1356795750, ペプチド骨格変換酵素の試験管内流用による機能性擬天然ペプチドの創製, トリプトファン残基のプレニル化の普遍性と機能解明研究, G3968410078, G4207287620, ペプチド修飾酵素の流用と拡張による含窒素芳香環のプレニル化触媒の開発, G5256761162, 天然物BGCにコードされた輸送体の解析手法の確立と機能解明, G7267730088, G7801973387, 非標準アミノ酸含む人工直交型ファージシステムの開発, G8985749466

OpenAlex ID: W7166869519

FWCI: 7.314

Cites: 67

Cited by: 2

Related to: 10