Adult-Onset Recessive Cerebellar Ataxia and Severe Multisystem Disease-Associated Genes: Hypomorphic Alleles and Clinical Interpretation Pitfalls
Year: 2026
Type: article
Abstract: BACKGROUND: Adult-onset recessive cerebellar ataxias remain frequently unresolved after next-generation sequencing, partly because phenotype-driven filtering can deprioritize biallelic variants in genes historically associated with severe pediatric multisystem disease. This review examines how attenuated, hypomorphic, or residual-function genotypes may present as late-onset, cerebellar-predominant disease and aims to support clinical interpretation of apparently discordant recessive findings. METHODS: We performed a narrative, pathway-based synthesis of autosomal recessive adult- or late-onset ataxia involving genes classically linked to lysosomal/neuronal ceroid lipofuscinosis and peroxisomal disorders. Reports were assessed for age at onset, cerebellar and extracerebellar chronology, variant class, zygosity, segregation/in-trans confirmation, biochemical or functional evidence, and implications for clinician-laboratory interpretation. RESULTS: Published reports indicate that selected NCL-related and peroxisomal genes may be clinically relevant in adult-onset cerebellar ataxia, especially when accompanied by retinal disease, hearing loss, neuropathy, cognitive or psychiatric features, epilepsy/myoclonus, movement-disorder signs, or subtle biochemical abnormalities. Apparent phenotype-gene discordance may be compatible with residual function, allelic-series effects, and cerebellar selective vulnerability, although evidence is often limited to case reports or small series with variable segregation, biochemical, and functional support. We propose a workflow based on structured phenotype transfer, in-trans confirmation, targeted re-phenotyping, ACMG/AMP-informed evidence weighting, and avoidance of label-based exclusion from "ataxia gene" lists. CONCLUSIONS: Adult-onset recessive ataxia should not be interpreted only through canonical pediatric disease labels. A pathway-aware, phenotype-complete approach may reduce avoidable VUS retention and improve recognition of attenuated genetic presentations.
Source: Genes
Authors: Lorenzo Cipriano, Roberta Petillo, Manuela Priolo, Paola D’Ambrosio
Institution: Ospedale Antonio Cardarelli
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,137
OpenAlex ID: W7166869764