Work

Cryogel-based therapeutic platforms for disease modification in osteoarthritis

Year: 2026

Type: article

Abstract: Osteoarthritis (OA) is a leading cause of chronic pain and disability, and lacks disease-modifying therapies. Unlike conventional hydrogels, which suffer from poor mechanical robustness and limited retention, cryogels overcome existing limitations through their interconnected pore architecture, shape-memory behavior, and fatigue-resistant mechanics. Here, we review how cryogels are being engineered as platforms for stem cell delivery, bioactive molecule release, localized gene activation, and immunomodulation, and discuss key translation challenges.

Source: npj Biomedical Innovations.

DOI: 10.1038/s44385-026-00094-6

Authors: Jewelia A. Durant, Maria Eduarda Torres Gouveia, Aleyna E. La Croix, Adithya R. Puninchittaya, Katherine R. Hixon

Institution: Dartmouth College

Language: English

Topic: Hydrogels: synthesis, properties, applications

Subfield: Molecular Medicine

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,690