Work

Biological Activity and Structure–Activity Relationship of Mono- and Bis-Derivatives of 3-(Arylamino)propanehydrazides

Year: 2026

Type: article

Abstract: A series of N’-(4-nitrobenzylidene)propanehydrazides and corresponding bishydrazones, as well as N-(1,3-dioxoisoindolin-2-yl)propanamides and corresponding bis(propanamides), were synthesised. Antioxidant properties were assessed using reducing power, FRAP, DPPH, ABTS radical scavenging, and NBT inhibition assays. Among the tested compounds, phenylaminopropanamide 17 demonstrated the highest activity, showing 1.70-fold higher reducing power and 6.71-fold higher DPPH radical scavenging activity compared to melatonin. Phenylaminopropanehydrazide 9 exhibited the highest activity in the FRAP assay (1.48 times higher than melatonin), while ethoxyphenyl-based bis(propanamide) 24 showed the greatest NBT inhibition (1.58-fold relative to melatonin). Four compounds exhibited moderate antibacterial activity against both Gram-positive and Gram-negative bacteria.

Source: Biomolecules

DOI: 10.3390/biom16070975

Authors: Ingrida Tumosienė, Ilona Jonuškienė, Neringa Petrašauskienė, Kristina Kantminienė

Institution: Kaunas University of Technology

Language: English

Topic: Free Radicals and Antioxidants

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,258