Genes near tRNA are enriched in translational machinery
Year: 2026
Type: article
Abstract: The purpose of this work is to analyze gene enrichment patterns near tRNAs from the y1000+ dataset. Genes closest to tRNAs were identified using bedtools, and those genes were matched to KEGG IDs and GO IDs for further analysis. Over-representation analysis was performed using the R package Cluster Profiler, gene set enrichment analysis was run with gseKEGG R package, and gene ontology analysis was run with the topGO R package. Distance from various functional annotation groups was analyzed by pulling KEGG IDs from the following categories: aminoacyl tRNA, fatty acid, glycolysis, proteasome, ribosomal pathway, and ribosomal proteins. rRNA was found with Infernal, and tRNA modifications (citation to come). This work also investigated tRNA and rRNA locations with sequences that had chromosome level assembly to compare distributions between species.
Source: Figshare
Authors: Caroline West, Abigail Leavitt LaBella
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W7167027295
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