Work

18F-FDG PET/MRI–guided localization of pain generators in chronic neck pain associated with presumed cervical dystonia

Year: 2026

Type: article

Abstract: Background Localization of clinically relevant pain generators remains a major diagnostic challenge. MRI frequently demonstrates structural abnormalities that may lack symptomatic correlation, limiting identification of true nociceptive targets. ¹⁸F-FDG PET/MRI enables simultaneous metabolic and anatomical assessment and may help identify clinically actionable pain generators. Case Presentation: A 68-year-old man with chronic refractory neck pain underwent ¹⁸F-FDG PET/MRI, which demonstrated focal hypermetabolism within the right obliquus capitis inferior and right longus colli muscles without corresponding structural MRI abnormalities. In conjunction with clinical findings, imaging results supported a presumptive diagnosis of cervical dystonia. Targeted CT-guided corticosteroid injection followed by botulinum toxin injection was temporally associated with marked symptomatic improvement. Conclusion ¹⁸F-FDG PET/MRI may help localize metabolically active pain generators not identified on conventional imaging and support hypothesis-driven image-guided procedural targeting in selected patients with unexplained persistent pain.

Source: Discover Neuroscience

DOI: 10.1186/s13064-026-00284-3

Authors: Taksh Thakur, Seth Taylor, Ali Pirasteh, Joseph McGinley, Sandip Biswal

Institution: University of Wisconsin–Madison

Language: English

Topic: Neurological disorders and treatments

Subfield: Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W7167036335