Supplemental Figure 3. from Comprehensive Multiplatform Tyrosine Kinase Profiling Reveals Novel Actionable FGFR Aberrations across Sarcomas Affecting the Young
Year: 2026
Type: supplementary-materials
Abstract: A) Heatmap visualizing RNA expression (TPM) of TKs across the sarcoma cohort ordered based on sarcoma histology. RNA expression (Z-score) for B) JAK1, C) PDGFRB or D) PDGFRL in the ZERO cohort. Colors indicate specific samples as shown in legend. EWS: Ewing sarcoma, FP-RMS: fusion-positive rhabdomyosarcoma, FN-RMS: fusion-negative rhabdomyosarcoma, OS: osteosarcoma, MRT: malignant rhabdoid tumor, MPNST: malignant peripheral nerve sheath tumor, ASPS: alveolar soft part sarcoma, AS: angiosarcoma, IFS: infantile fibrosarcoma, DSRCT: desmoplastic small round blue cell tumor, GIST: gastrointestinal stromal tumor, SynS: synovial sarcoma, GNET: gastrointestinal neuroectodermal tumor, HGU: high-grade undifferentiated sarcoma, AF: ameloblastic fibrosarcoma, CIC: CIC-rearranged sarcoma, EPI: epithelioid sarcoma, FMX: low-grade fibromyxoid sarcoma, Round cell: EWSR1-PATZ1 round cell sarcoma, desmoid: desmoid tumor.
Authors: Ashleigh M. Fordham, Lauren M. Brown, Chelsea Mayoh, Alice Salib, Zara A. Barger, Marie Wong, Terry C.C. Lim Kam Sian, Changyuan Hu, Jinhan Xie, Kate Gunther, Peter Trebilcock, Rachael L. Terry, Paulette Barahona, Pamela Ajuyah, Alexandra Sherstyuk, Anica Avila, Roxanne Cadiz, Callum M. Perkins, Andrew J. Gifford, Jie Mao, M. Emmy M. Dolman, Andrea Zhao, Luke P. O’Regan, Daniel Gorgels, Loretta M.S. Lau, David S. Ziegler, Michelle Haber, Vanessa Tyrrell, Richard B. Lock, Mark J. Cowley, Wayne Nicholls, Roger J. Daly, Paul G. Ekert, Emmy D.G. Fleuren
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W7167061205