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Supplementary Figure S11 from Adaptive Regulation of dNTP Homeostasis Confers Osimertinib Resistance in EGFR-Mutant Non–Small Cell Lung Carcinoma

Year: 2026

Type: supplementary-materials

Abstract: dNTP depletion caused by Osimertinib is time dependent, and RRM2 and RRM2B expression profiles are distinct in Osimertinib resistant cells. Resistant cells upregulate expression of genes in salvage pathways.

DOI: 10.1158/0008-5472.32873087

Authors: Qian Xie, Yingying Wang, Anthony Fernandez, Yi Lei, Yuanhang Gong, Jessica D. Hess, Lin Yang, Di Xin, Terence M. Williams, Li Zheng, Binghui Shen, Min Li

Topic: Lung Cancer Treatments and Mutations

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W7167097243

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