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Köpeklerde Kardiyovasküler Hastalıklarda Nutrigenomik: Diyet Kaynaklı Moleküler Düzenlemeler ve Klinik Etkiler

Year: 2026
Type: article
Abstract: Nutrigenomics is an interdisciplinary field that investigates the effects of nutrients on gene expression and aims to elucidate the molecular interactions between diet and genetic background. In veterinary medicine, nutrigenomic approaches have gained increasing importance, particularly in understanding the pathogenesis of cardiovascular diseases. In dogs, common conditions such as dilated cardiomyopathy and congestive heart failure are influenced by complex interactions between genetic predisposition and environmental factors, including dietary components.This review focuses on the role of nutrigenomic mechanisms in the development and progression of cardiac diseases in dogs. Particular emphasis is placed on the regulatory effects of nutrients such as omega-3 fatty acids, taurine, and carnitine on inflammation, oxidative stress, and energy metabolism. In addition, the contribution of epigenetic mechanisms, microRNAs, and cellular signaling pathways to cardiac remodeling processes is discussed in the context of diet–gene interactions.Evidence from both veterinary and human studies indicates that nutrients exert not only metabolic effects but also direct regulatory influences on gene expression and cellular responses. Diet-associated dilated cardiomyopathy and micronutrient deficiencies leading to cardiac dysfunction highlight the clinical relevance of nutrigenomic perspectives.In conclusion, nutrigenomic approaches hold significant potential for improving the understanding and management of cardiovascular diseases in dogs. Future developments integrating genetic background, metabolic responses, and dietary components may enable the establishment of personalized nutritional strategies in veterinary cardiology.
Language: Turkish
Subfield: Genetics
Open Access status: green
OpenAlex ID: W7167172438
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