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Severe Cardiomyopathy Following Takotsubo Syndrome in a Patient Suffering from Eosinophilic Granulomatosis With Polyangiitis: A Case Report

Year: 2026

Type: article

Abstract: Cardiac involvement in eosinophilic granulomatosis with polyangiitis (EGPA) strongly influences the prognosis. Takotsubo syndrome (TTS) is a reversible stress-induced cardiomyopathy that has rarely been reported in patients with EGPA. A 39-year-old woman was diagnosed with EGPA based on marked eosinophilia, systemic manifestations, and the histopathological eosinophilic infiltration of multiple organs. After remission with corticosteroids, immunosuppressants, and intravenous immunoglobulin, she suddenly developed chest pain with an ST elevation and severe left ventricular dysfunction, but normal coronary angiography findings. TTS was diagnosed. Her cardiac function recovered. However, an endomyocardial biopsy revealed advanced myocardial injury without eosinophilic infiltration. Therapy (corticosteroids, immunosuppressants, intravenous immunoglobulin, and mepolizumab) achieved long-term survival despite severe cardiac involvement.

Source: Internal Medicine

DOI: 10.2169/internalmedicine.7487-26

Authors: Yuga Yamashita, Chiyako Oshikata, Nami Masumoto, Sachiko Takaoka, Takuya Nakashima, Kaho Matsunaga, Yuka Kodama, Kosuke Terada, Hinako Masumitsu, Atsushi Miyasaka, Tatsuya Muraoka, Takeshi Kaneko, Naomi Tsurikisawa

Institutions: National Hospital Organization Yokohama Medical Center, Yokohama City University

Language: English

Topic: Takotsubo Cardiomyopathy and Associated Phenomena

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W7167203853

FWCI:

Cites: 26

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Related to: 10