Acute Kidney Injury Due to Granulomatous Interstitial Nephritis as the Initial Presentation of CLL/SLL Treated with Acalabrutinib
Year: 2026
Type: article
Study design: Case Report
Abstract: Acute kidney injury (AKI) caused by granulomatous interstitial nephritis (GIN) accompanied by chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) is extremely rare. A 71-year-old man with severe AKI was diagnosed with CLL/SLL based on bone marrow and lymph node biopsy results. A renal biopsy revealed dense cortical infiltration of CLL/SLL cells and severe interstitial inflammation with granuloma formation, consistent with GIN. Acalabrutinib-Obinutuzumab combination therapy was effective for CLL/SLL, but prednisolone was required to achieve a renal function improvement. A renal biopsy is essential for the diagnosis, and corticosteroids play a key role in managing GIN-associated renal injury, even in the era of targeted therapies.
Source: Internal Medicine
Authors: Asuka Shibamiya, Chikako Ohwada, Akane Tanaka, Reiko Watanabe, Jun Ito, Yuichiro Hayashi, Takayuki Shiomi, Chiaki Nakaseko
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W7167242627