Work

Partial breast irradiation after lumpectomy with omission of surgical axillary evaluation

Year: 2026

Type: preprint

Abstract: Sentinel lymph node biopsy (SLNB) is increasingly omitted in early-stage breast cancer, often prompting whole-breast irradiation (WBI). We evaluated partial-breast irradiation (PBI) without axillary surgery among 78 clinically node-negative patients (median age 75) treated from 2014-2022. After 53-month median follow-up, no ipsilateral, regional, or distant recurrences occurred. These results demonstrate excellent outcomes and suggest PBI is a feasible, safe alternative to WBI when SLNB is omitted.

Source: medRxiv

DOI: 10.64898/2026.06.29.26356836

Authors: Diana A. Roth O’Brien, Lillian A. Boe, Boris A. Mueller, Giacomo Montagna, Emma N. Hahesy, John J. Cuaron, J. Isabelle Choi, Michael B. Bernstein, Beryl McCormick, Simon N. Powell, Atif J. Khan, Lior Z. Braunstein

Institution: Memorial Sloan Kettering Cancer Center

Language: English

Topic: Breast Cancer Treatment Studies

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W7167366447

Cites: 15

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Related to: 10