Year: 2025
Type: article
Study design: Observational Study
Abstract: In the course of chronic kidney insufficiency due to renal impairment almost more than 50% of deaths among patients with end – stage renal disease are due to cardiovascular diseases [6]. The risk of death was higher in hemodialysed than general population. Increased mortality rate as a result of damaged cardiac tissues after calcification may lead to abnormal conduction and arrhythmia, left ventricular dysfunction, aortic and mitral stenosis and regurgitation, complete heart block, ischemia, congestive cardiac failure and death [7]. Our aim was to determine the prevalence of valvular calcification and coronary artery calcification in peritoneal dialysis patients and to examine some possible etiologic factors for its occurrence. Calcification complications are frequent among peritoneal dialysis patients. In this study, we have found that coronary vessels calcification is a common finding in 70% group of peritoneal dialysis. However, we found a negative correlation in the concentration of fetuin-A between volumetric units and Agatson score which indicates that it is deficiency of fetuin-A, fundamental of this pathology. VC is mainly characteristic of patients with high indices of coronary vessels calcification. In our study, patients with valvular calcification (VC) had significantly lower concentrations of fetuin-A than patients without VC. We found an important association between fibrinogen, CRP as a biological marker of inflammation and calcification mechanism. This factors and fetuin-A, being so involved in this process, can be predictive factors for evaluation of risk of calcification above osteal and also atherosclerosis. In addition, the elevated level of CRP is associated with mitral valve calcification. Our results indicate that valvular calcification may be useful in stratifying the severity of atherosclerotic vascular disease in peritoneal dialysis patients. In summary, our study shows important association between, inflammation: CRP, fibrinogen and serum fetuin-A in peritoneal dialysis patients.
Institution: Medical University of Lublin
Language: English
Subfield: Nephrology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $84
OpenAlex ID: W7167452321