Work

Intranasal and intramuscular H5-Matrix-M nanoparticle vaccines protects against highly pathogenic Influenza A (H5N1) virus in mice [dataset]

Year: 2026

Type: dataset

Abstract: In this work, we characterized the immunogenicity and efficacy of a Matrix-M®–adjuvanted nanoparticle protein vaccine containing recombinant H5 HA of A/American wigeon/South Carolina/22/000345-001/2021 virus (clade 2.3.4.4b, H5-MNP). Influenza A virus (H5N1) animal challenge model involves BL/6 mice and Madin-Darby Canine Kidney epithelial (MDCK) cells. Data types include Reverse transcriptase quantitative polymerase chain reaction (RT-qPCR) imputed values from Quant Studio, Focus-forming assay (FFA) values from CTL Biospot, histological images, and weight loss data.

Source: Mendeley Data

DOI: 10.17632/x8b2f87c99

Authors: Pyles, Kelly, Darling, Tamarand, Huang, Lin-Chen, Guebre-Xabier, Mimi, Hersey, Melinda, Greene, Annie, Patel, Nita, Smith, Gale, Boon, Adrianus CM

Institutions: Washington University in St. Louis, Novavax (United States)

Language: English

Topic: Influenza Virus Research Studies

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: Novavax

OpenAlex ID: W7167477177

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Related to: 10