Therapeutic Potential of Selected HDAC Targeting in Mature T-cell Neoplasms
Year: 2025
Type: dissertation
Abstract: This dissertation investigates the therapeutic potential of selected HDAC-targeting strategies in mature T-cell neoplasms, with a particular focus on T-prolymphocytic leukemia (T-PLL). It examines the biological and therapeutic effects of HDAC inhibitors and combination approaches in relevant cellular models. The study identifies pan-HDAC inhibitors as particularly active compounds and shows that their anti-tumor effects are associated with histone acetylation, PARP cleavage, and reactivation of p53-dependent apoptotic pathways. In addition, combination strategies involving venetoclax and BCL-2 family inhibitors demonstrate enhanced efficacy, especially in venetoclax-resistant settings. Further analyses suggest that specific molecular vulnerabilities may underlie treatment response and resistance. Overall, this work provides preclinical evidence supporting HDAC-based and rational combination therapies as promising treatment strategies for mature T-cell neoplasms, particularly T-PLL.
Author: Peng, Yayi
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W7167649049