Prophylactic Antibiotic Treatment Duration in Preterm Premature Rupture of Membrane 7 Days Versus Until Delivery
Year: 2026
Type: dissertation
Abstract: Previously referred to as preterm premature rupture of membranes, pretermprelabour rupture of membrane (PPROM) defines spontaneous membranerupture before 37 completed weeks and before labour onset”1.PPROM mainly for 2-3% of all complicated pregnancies and is one of themajor causes of preterm deliveries2.Risk factors for PPROM include intrauterine infection at early gestationalage,oxidative stress- induced DNA damage and premature cellular senescence,inappropriate prenatal care, nutritional deficiency during pregnancy, low bodymass index, lower socioeconomic status, sexually transmitted diseases, vaginalbleeding and smoking3.Complications do occur in both mother and neonate2. Maternal complicationsinclude chorioaminonitis, abruptio placentae and postpartum infection. Neonatalcomplications include respiratory distress syndrome (RDS), neonatal sepsis,cerebral palsy and necrotizing enterocolitis (NEC)4.18Docusign Envelope ID: EB2F53F4-895F-4FC0-8DDE-4CD64CA34EC7Due to changes in hormonal and vaginal environment, imbalance occurs in thevaginal flora followed by colonization by potentially harmful microorganismswhich include E. coli, Streptococcus sp, Mycoplasma hominis, Ureaplasmaurealyticum5.In order to prevent neonatal and maternal morbidity and mortality, efforts aremade to prolong the latent period between PPROM and the onset of labor andalso to prevent infection-associated complications6.It is commonly known that the most effective way to extend the time betweenROManddelivery in individuals with PPROM3 is to treat them with antibiotics.Whenbroad-spectrum antibiotics are administered to women with PPROM,pregnancy is prolonged and some short-term newborn morbidities are decreased.Although a number of antibiotic regimens have shown promise for PPROM, itis uncertain which is the most effective. 7.Selection of antibiotic regimen and the duration of the treatment vary amonghospitals. When compared to a 7-day regimen, prolonged use of antibiotictreatment until delivery will be more beneficial8.In this current study in order to have a better understanding for proper selectionand duration of course of antibiotic regimen, a prophylactic antibiotic therapywith intravenous ceftrixone, metranidazole and oral clarithromycin in patientswith PPROM was conducted.
Authors: GUDDAD SHABANA HAMEED, SHOBHA SHIRAGUR
Institution: BLDE (Deemed to be University)
Language: English
Subfield: Obstetrics and Gynecology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7167696339