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On the Increased and Decreased Connectivity of the Demented Human Brain

Year: 2026
Type: preprint
Abstract: With major advances in cerebral imaging techniques, a large amount of data is available for studying the aging and demented brain. In this contribution, we apply the OASIS-3 dataset to identify small areas of human gray matter with higher or lower structural connectivity in dementia. As was anticipated, we have found that finer structures of the hippocampus and the temporal lobe have decreased connectivity in dementia. More surprisingly, the precuneus, the cuneus, and some finer structures of the insula, the paracentral lobule, and the precentral and paracentral gyri showed higher connectivity in dementia than in healthy subjects.
Source: PubMed
DOI: 10.48550/arxiv.2607.05654
Language: English
Open Access status: green
Funders: Eötvös Loránd Tudományegyetem, National Institutes of Health, Nemzeti Kutatási, Fejlesztési és Innovaciós Alap, National Institute on Aging, National Institute of Neurological Disorders and Stroke, National Institute of Biomedical Imaging and Bioengineering
Awards: G4183452178, DRIVING PERFORMANCE IN PRECLINICAL ALZHEIMER'S DISEASE, G660829768, Healthy Aging and Senile Dementia, G721023497, Washington University Institute of Clinical and Translational Sciences, NINDS CENTER CORE FOR BRAIN IMAGING, G878884674, G9000112288, G9000115080, THE XNAT IMAGING INFORMATICS PLATFORM, Antecedent Biomarkers for Alzheimer Disease: The Adult Children Study
OpenAlex ID: W7167700470
Cites: 1
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Related to: 10