Post–genome-wide association study variant-to-function challenges in asthma research
Year: 2026
Type: review
Abstract: Genome-wide association studies of asthma have identified nearly 200 independent loci, yet the mechanisms through which individual loci influence asthma risk remain largely unknown. A growing array of computational and experimental tools has begun to fill these gaps by identifying causal variants and effector genes and characterizing their functions. In parallel, emerging studies are exploring the translational applications of genetic and multiomics data in asthma, including defining molecular endotypes and predicting disease risk. Here we review the strengths and limitations of current approaches for addressing the post-genome-wide association study challenges and discuss the next tier of questions and directions for the field.
Institution: University of Chicago
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,900
Awards: Childhood Allergy and the NeOnatal Environment (CANOE) ECHO Pediatric Follow-Up and New Enrollment, Integrated genetic, omic, and immunologic studies to identify endotypes and novel drug targets for asthma and allergic diseases, Research training in respiratory biology, Controlling and Preventing Asthma Progression and Severity in Kids with Omalizumab Extension (PARK-EXT), Childhood Asthma in Urban Settings Clinical Research Network - Leadership Center, Children's Allergy and Asthma Data Repository (CADRE)
OpenAlex ID: W7167790190